Drug interactions
Cevimeline + Fluconazole
Severity: Minor
Cevimeline and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is partly metabolized by CYP3A4 and CYP2D6. Fluconazole, a moderate CYP3A4 inhibitor, may raise cevimeline exposure and increase cholinergic effects such as sweating, nausea, diarrhea or bradycardia.
What this interaction means in plain words
Cevimeline and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cevimeline belongs to Miscellaneous; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4-mediated metabolism of cevimeline, increasing its plasma concentrations.
What to do
No routine dose change is needed; monitor for cholinergic adverse effects such as excessive sweating, GI upset or slow heart rate, especially in patients with cardiac disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Fluconazole?
MediHelp rates the interaction as minor. Cevimeline and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cevimeline is partly metabolized by CYP3A4 and CYP2D6. Fluconazole, a moderate CYP3A4 inhibitor, may raise cevimeline exposure and increase cholinergic effects such as sweating, nausea, diarrhea or bradycardia.
How serious is the interaction between Cevimeline and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for cholinergic adverse effects such as excessive sweating, GI upset or slow heart rate, especially in patients with cardiac disease.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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