Drug interactions
Cevimeline + Sotalol
Severity: Moderate
Cevimeline and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist that can slow heart rate and conduction. Combined with sotalol, which also slows the heart and prolongs repolarization, bradycardia or conduction disturbances may be more likely, particularly in susceptible patients.
What this interaction means in plain words
Cevimeline and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Sotalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on heart rate and AV conduction (cholinergic stimulation plus beta-blockade).
What to do
Monitor heart rate and ECG when starting cevimeline in patients on sotalol. Consider an alternative in patients with baseline bradycardia, heart block or QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Sotalol?
MediHelp rates the interaction as moderate. Cevimeline and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist that can slow heart rate and conduction. Combined with sotalol, which also slows the heart and prolongs repolarization, bradycardia or conduction disturbances may be more likely, particularly in susceptible patients.
How serious is the interaction between Cevimeline and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG when starting cevimeline in patients on sotalol. Consider an alternative in patients with baseline bradycardia, heart block or QT prolongation.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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