Drug interactions
Cevimeline + Trimipramine
Severity: Moderate
Cevimeline and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist and trimipramine blocks muscarinic receptors, so each may reduce the effect of the other. Trimipramine may weaken the relief of dry mouth, and cevimeline is also metabolized by CYP2D6 and CYP3A4.
What this interaction means in plain words
Cevimeline and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Trimipramine belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition at muscarinic receptors.
What to do
Monitor saliva response and tolerability. Consider a less anticholinergic antidepressant if dry mouth symptoms are not controlled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Trimipramine?
MediHelp rates the interaction as moderate. Cevimeline and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist and trimipramine blocks muscarinic receptors, so each may reduce the effect of the other. Trimipramine may weaken the relief of dry mouth, and cevimeline is also metabolized by CYP2D6 and CYP3A4.
How serious is the interaction between Cevimeline and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor saliva response and tolerability. Consider a less anticholinergic antidepressant if dry mouth symptoms are not controlled.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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