Drug interactions
Finerenone + Phenobarbitone
Severity: Major
Finerenone and Phenobarbitone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces CYP3A4 and is expected to lower finerenone concentrations, reducing efficacy.
What this interaction means in plain words
Finerenone and Phenobarbitone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Finerenone belongs to Cardiovascular; Phenobarbitone belongs to Central Nervous System.
Why it happens
CYP3A4 induction by phenobarbital accelerates finerenone clearance.
What to do
Avoid coadministration; consider a non-inducing anticonvulsant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Other interactions of Phenobarbitone
- Cabotegravir + Phenobarbitone Contraindicated
- Doravirine + Phenobarbitone Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Darolutamide + Phenobarbitone Major
- Ivacaftor + Phenobarbitone Major
- Letermovir + Phenobarbitone Major
Frequently asked questions
Can I take Finerenone with Phenobarbitone?
MediHelp rates the interaction as major. Finerenone and Phenobarbitone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenobarbital induces CYP3A4 and is expected to lower finerenone concentrations, reducing efficacy.
How serious is the interaction between Finerenone and Phenobarbitone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; consider a non-inducing anticonvulsant.
What other medicines interact with Finerenone?
MediHelp also lists interactions of Finerenone with, for example, Carbamazepine, Clarithromycin, Ensitrelvir. The full list is on the Finerenone page.
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