Drug interactions
Chloral hydrate + Fenfluramine
Severity: Moderate
Chloral hydrate and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine is a serotonergic agent used for seizures in Dravet and Lennox-Gastaut syndromes and can cause somnolence or fatigue. Combined with chloral hydrate, additive sedation is possible, while any stimulant opposition is not reliable.
What this interaction means in plain words
Chloral hydrate and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; fenfluramine's serotonergic action does not reliably offset sedation.
What to do
Monitor for excessive somnolence and impaired alertness, especially in children. Adjust the sedative dose if drowsiness is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Chloral hydrate with Fenfluramine?
MediHelp rates the interaction as moderate. Chloral hydrate and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine is a serotonergic agent used for seizures in Dravet and Lennox-Gastaut syndromes and can cause somnolence or fatigue. Combined with chloral hydrate, additive sedation is possible, while any stimulant opposition is not reliable.
How serious is the interaction between Chloral hydrate and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive somnolence and impaired alertness, especially in children. Adjust the sedative dose if drowsiness is excessive.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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