Drug interactions
Chloral hydrate + Melatonin
Severity: Minor
Chloral hydrate and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has mild sedative effects and may add modestly to the drowsiness caused by chloral hydrate. Clinically significant oversedation is uncommon.
What this interaction means in plain words
Chloral hydrate and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloral hydrate belongs to Central Nervous System; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Mild additive sedation through melatonin receptor effects on sleep with a GABAergic hypnotic.
What to do
No dose change is usually needed; advise patients to report excessive daytime drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Chloral hydrate with Melatonin?
MediHelp rates the interaction as minor. Chloral hydrate and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has mild sedative effects and may add modestly to the drowsiness caused by chloral hydrate. Clinically significant oversedation is uncommon.
How serious is the interaction between Chloral hydrate and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; advise patients to report excessive daytime drowsiness.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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