Drug interactions
Chloral hydrate + Modafinil
Severity: Minor
Chloral hydrate and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil promotes wakefulness whereas chloral hydrate is a sedative, so the two have opposing effects with an unpredictable net outcome. No established pharmacokinetic interaction exists, and combined use is rarely appropriate.
What this interaction means in plain words
Chloral hydrate and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloral hydrate belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on arousal; no established mechanism of toxicity.
What to do
Review whether both drugs are needed and monitor sleep and alertness. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Modafinil
Frequently asked questions
Can I take Chloral hydrate with Modafinil?
MediHelp rates the interaction as minor. Chloral hydrate and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil promotes wakefulness whereas chloral hydrate is a sedative, so the two have opposing effects with an unpredictable net outcome. No established pharmacokinetic interaction exists, and combined use is rarely appropriate.
How serious is the interaction between Chloral hydrate and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review whether both drugs are needed and monitor sleep and alertness. No routine dose change is needed.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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