Drug interactions
Chloral hydrate + Pregabalin
Severity: Moderate
Chloral hydrate and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloral hydrate and pregabalin both cause sedation, and combining them can intensify drowsiness, dizziness, cognitive impairment and respiratory depression. Vulnerable patients such as older adults or those with respiratory disease are at highest risk.
What this interaction means in plain words
Chloral hydrate and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Start with low doses and titrate carefully, monitoring sedation and breathing. Avoid other CNS depressants where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Chloral hydrate with Pregabalin?
MediHelp rates the interaction as moderate. Chloral hydrate and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloral hydrate and pregabalin both cause sedation, and combining them can intensify drowsiness, dizziness, cognitive impairment and respiratory depression. Vulnerable patients such as older adults or those with respiratory disease are at highest risk.
How serious is the interaction between Chloral hydrate and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate carefully, monitoring sedation and breathing. Avoid other CNS depressants where possible.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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