Drug interactions
Chloral hydrate + Risperidone
Severity: Moderate
Chloral hydrate and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of a sedative-hypnotic with an antipsychotic can increase drowsiness, dizziness and psychomotor impairment. Risperidone may also cause orthostatic hypotension, which can compound fall risk.
What this interaction means in plain words
Chloral hydrate and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABAergic enhancement and risperidone antagonism of histamine H1 and alpha-1 adrenergic receptors.
What to do
Use the lowest effective doses and monitor sedation and orthostatic blood pressure, especially in elderly or pediatric patients. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Chloral hydrate with Risperidone?
MediHelp rates the interaction as moderate. Chloral hydrate and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a sedative-hypnotic with an antipsychotic can increase drowsiness, dizziness and psychomotor impairment. Risperidone may also cause orthostatic hypotension, which can compound fall risk.
How serious is the interaction between Chloral hydrate and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and orthostatic blood pressure, especially in elderly or pediatric patients. Avoid alcohol and other sedatives.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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