Drug interactions
Chloral hydrate + Trimipramine
Severity: Moderate
Chloral hydrate and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a highly sedating tricyclic antidepressant and chloral hydrate is a hypnotic, so together they can cause marked sedation and psychomotor impairment. Tricyclics also carry anticholinergic, hypotensive and arrhythmic risks that may be compounded in vulnerable patients.
What this interaction means in plain words
Chloral hydrate and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABAergic effects and the antihistaminic and alpha-1 blocking properties of trimipramine.
What to do
Use the lowest effective doses and monitor sedation, blood pressure and heart rhythm, particularly in elderly patients or those with cardiac disease. Avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Chloral hydrate with Trimipramine?
MediHelp rates the interaction as moderate. Chloral hydrate and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a highly sedating tricyclic antidepressant and chloral hydrate is a hypnotic, so together they can cause marked sedation and psychomotor impairment. Tricyclics also carry anticholinergic, hypotensive and arrhythmic risks that may be compounded in vulnerable patients.
How serious is the interaction between Chloral hydrate and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, blood pressure and heart rhythm, particularly in elderly patients or those with cardiac disease. Avoid alcohol.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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