Drug interactions
Chloramphenicol + Crizotinib
Severity: Moderate
Chloramphenicol and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is metabolized mainly by CYP3A4, and chloramphenicol may inhibit this enzyme and raise crizotinib exposure. This could increase hepatotoxicity, QT prolongation and bradycardia.
What this interaction means in plain words
Chloramphenicol and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Crizotinib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing crizotinib clearance; the aldehyde dehydrogenase mechanism is not supported.
What to do
Monitor liver enzymes, heart rate and ECG, and consider an alternative antibiotic. If crizotinib toxicity occurs, interrupt or reduce the dose according to labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Crizotinib?
MediHelp rates the interaction as moderate. Chloramphenicol and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is metabolized mainly by CYP3A4, and chloramphenicol may inhibit this enzyme and raise crizotinib exposure. This could increase hepatotoxicity, QT prolongation and bradycardia.
How serious is the interaction between Chloramphenicol and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, heart rate and ECG, and consider an alternative antibiotic. If crizotinib toxicity occurs, interrupt or reduce the dose according to labeling.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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