Drug interactions
Chloramphenicol + Daridorexant
Severity: Moderate
Chloramphenicol and Daridorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daridorexant is cleared mainly by CYP3A4, so inhibitors increase exposure and may cause excessive somnolence and next-day impairment. Chloramphenicol may have such an effect.
What this interaction means in plain words
Chloramphenicol and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Daridorexant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of daridorexant.
What to do
Use the lowest daridorexant dose and monitor for daytime sedation. Counsel patients about driving and other alertness-requiring activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Daridorexant
Frequently asked questions
Can I take Chloramphenicol with Daridorexant?
MediHelp rates the interaction as moderate. Chloramphenicol and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Daridorexant is cleared mainly by CYP3A4, so inhibitors increase exposure and may cause excessive somnolence and next-day impairment. Chloramphenicol may have such an effect.
How serious is the interaction between Chloramphenicol and Daridorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest daridorexant dose and monitor for daytime sedation. Counsel patients about driving and other alertness-requiring activities.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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