Drug interactions
Chloramphenicol + Dasatinib
Severity: Major
Chloramphenicol and Dasatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may increase dasatinib concentrations because dasatinib is a CYP3A4 substrate. Higher exposure may worsen myelosuppression, fluid retention and QT prolongation. Chloramphenicol itself also suppresses bone marrow, so hematologic toxicity may be additive.
What this interaction means in plain words
Chloramphenicol and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Dasatinib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4-mediated dasatinib metabolism, and both drugs have myelosuppressive effects.
What to do
Avoid the combination if an alternative antibiotic exists. Otherwise monitor complete blood counts and ECG, and consider reducing the dasatinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Chloramphenicol with Dasatinib?
MediHelp rates the interaction as major. Chloramphenicol and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol may increase dasatinib concentrations because dasatinib is a CYP3A4 substrate. Higher exposure may worsen myelosuppression, fluid retention and QT prolongation. Chloramphenicol itself also suppresses bone marrow, so hematologic toxicity may be additive.
How serious is the interaction between Chloramphenicol and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative antibiotic exists. Otherwise monitor complete blood counts and ECG, and consider reducing the dasatinib dose.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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