Drug interactions
Chloramphenicol + Dicloxacillin
Severity: Minor
Chloramphenicol and Dicloxacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol is bacteriostatic and may reduce the bactericidal effect of dicloxacillin in vitro. Clinical impact is uncertain, but it could matter in severe infections.
What this interaction means in plain words
Chloramphenicol and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloramphenicol belongs to Anti Bacterial; Dicloxacillin belongs to Anti Bacterial.
Why it happens
Pharmacodynamic antagonism: inhibition of protein synthesis and growth reduces the activity of cell-wall-active penicillins.
What to do
Avoid combining when a bactericidal regimen is required, such as in meningitis or endocarditis; otherwise monitor clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Dicloxacillin?
MediHelp rates the interaction as minor. Chloramphenicol and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol is bacteriostatic and may reduce the bactericidal effect of dicloxacillin in vitro. Clinical impact is uncertain, but it could matter in severe infections.
How serious is the interaction between Chloramphenicol and Dicloxacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when a bactericidal regimen is required, such as in meningitis or endocarditis; otherwise monitor clinical response.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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