Drug interactions
Chloramphenicol + Dronedarone
Severity: Major
Chloramphenicol and Dronedarone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a CYP3A4 substrate and CYP3A4 inhibition raises its levels, increasing QT prolongation and proarrhythmic risk. Strong inhibitors are contraindicated with dronedarone, and chloramphenicol's inhibition is of uncertain strength.
What this interaction means in plain words
Chloramphenicol and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Dronedarone belongs to Cardiovascular.
Why it happens
Chloramphenicol inhibits CYP3A4, decreasing dronedarone clearance.
What to do
Avoid the combination and use a different antibiotic. If unavoidable, monitor ECG for QT prolongation and bradycardia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Dronedarone?
MediHelp rates the interaction as major. Chloramphenicol and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone is a CYP3A4 substrate and CYP3A4 inhibition raises its levels, increasing QT prolongation and proarrhythmic risk. Strong inhibitors are contraindicated with dronedarone, and chloramphenicol's inhibition is of uncertain strength.
How serious is the interaction between Chloramphenicol and Dronedarone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a different antibiotic. If unavoidable, monitor ECG for QT prolongation and bradycardia.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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