Drug interactions
Chloramphenicol + Ethinyl estradiol-drospirenone
Severity: Minor
Chloramphenicol and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol has been theorized to lower oral contraceptive effectiveness through gut flora changes, but evidence of contraceptive failure is sparse. Chloramphenicol can also inhibit hepatic enzymes, so the net effect is uncertain and probably small.
What this interaction means in plain words
Chloramphenicol and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloramphenicol belongs to Anti Bacterial; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Theoretical reduction of enterohepatic recirculation of ethinyl estradiol through gut flora changes; not well established.
What to do
No routine change is needed; advise backup contraception if vomiting or severe diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Chloramphenicol and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol has been theorized to lower oral contraceptive effectiveness through gut flora changes, but evidence of contraceptive failure is sparse. Chloramphenicol can also inhibit hepatic enzymes, so the net effect is uncertain and probably small.
How serious is the interaction between Chloramphenicol and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise backup contraception if vomiting or severe diarrhea occurs.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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