Drug interactions
Chloramphenicol + Fosaprepitant
Severity: Moderate
Chloramphenicol and Fosaprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a CYP3A4 substrate, so CYP3A4 inhibition by chloramphenicol could raise aprepitant levels. With single-dose fosaprepitant the clinical effect is probably modest and the combination is not clearly contraindicated.
What this interaction means in plain words
Chloramphenicol and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
CYP3A4 inhibition by chloramphenicol may decrease aprepitant clearance.
What to do
No routine dose change is needed; monitor for aprepitant adverse effects such as fatigue, hiccups and infusion-site reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Chloramphenicol with Fosaprepitant?
MediHelp rates the interaction as moderate. Chloramphenicol and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant is converted to aprepitant, a CYP3A4 substrate, so CYP3A4 inhibition by chloramphenicol could raise aprepitant levels. With single-dose fosaprepitant the clinical effect is probably modest and the combination is not clearly contraindicated.
How serious is the interaction between Chloramphenicol and Fosaprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for aprepitant adverse effects such as fatigue, hiccups and infusion-site reactions.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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