Drug interactions
Chloramphenicol + Haloperidol
Severity: Moderate
Chloramphenicol and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is partly metabolized by CYP3A4, so chloramphenicol may raise its levels. This may increase sedation, extrapyramidal symptoms and QT prolongation.
What this interaction means in plain words
Chloramphenicol and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Haloperidol belongs to Central Nervous System.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing haloperidol metabolism.
What to do
Monitor for extrapyramidal effects and sedation, and obtain an ECG if other QT-prolonging risks exist. Adjust the haloperidol dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Haloperidol?
MediHelp rates the interaction as moderate. Chloramphenicol and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol is partly metabolized by CYP3A4, so chloramphenicol may raise its levels. This may increase sedation, extrapyramidal symptoms and QT prolongation.
How serious is the interaction between Chloramphenicol and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal effects and sedation, and obtain an ECG if other QT-prolonging risks exist. Adjust the haloperidol dose accordingly.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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