Drug interactions
Chloramphenicol + Ivacaftor
Severity: Moderate
Chloramphenicol and Ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and raise ivacaftor exposure, increasing the risk of adverse effects such as liver enzyme elevation, headache and dizziness.
What this interaction means in plain words
Chloramphenicol and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Ivacaftor belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated metabolism of ivacaftor.
What to do
Reduce the ivacaftor dose per the product labeling for CYP3A inhibitors and monitor liver tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Chloramphenicol with Ivacaftor?
MediHelp rates the interaction as moderate. Chloramphenicol and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may inhibit CYP3A4 and raise ivacaftor exposure, increasing the risk of adverse effects such as liver enzyme elevation, headache and dizziness.
How serious is the interaction between Chloramphenicol and Ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ivacaftor dose per the product labeling for CYP3A inhibitors and monitor liver tests.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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