Drug interactions
Chloramphenicol + Levomilnacipran
Severity: Moderate
Chloramphenicol and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran is partly metabolized by CYP3A4, and inhibitors raise its levels. This may increase noradrenergic and serotonergic effects including hypertension, tachycardia and serotonin toxicity.
What this interaction means in plain words
Chloramphenicol and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Levomilnacipran belongs to Central Nervous System.
Why it happens
Chloramphenicol inhibits CYP3A4, decreasing levomilnacipran clearance.
What to do
Limit levomilnacipran to the labeled maximum for strong CYP3A4 inhibitors and monitor blood pressure, heart rate and serotonergic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Levomilnacipran?
MediHelp rates the interaction as moderate. Chloramphenicol and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levomilnacipran is partly metabolized by CYP3A4, and inhibitors raise its levels. This may increase noradrenergic and serotonergic effects including hypertension, tachycardia and serotonin toxicity.
How serious is the interaction between Chloramphenicol and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit levomilnacipran to the labeled maximum for strong CYP3A4 inhibitors and monitor blood pressure, heart rate and serotonergic symptoms.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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