Drug interactions
Chloramphenicol + Lomitapide
Severity: Major
Chloramphenicol and Lomitapide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a sensitive CYP3A4 substrate, and inhibitors raise its exposure considerably. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.
What this interaction means in plain words
Chloramphenicol and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Lomitapide belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated lomitapide metabolism.
What to do
Avoid the combination if possible, or limit the lomitapide dose per labeling for weak inhibitors. Monitor liver enzymes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Lomitapide?
MediHelp rates the interaction as major. Chloramphenicol and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lomitapide is a sensitive CYP3A4 substrate, and inhibitors raise its exposure considerably. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.
How serious is the interaction between Chloramphenicol and Lomitapide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or limit the lomitapide dose per labeling for weak inhibitors. Monitor liver enzymes.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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