Drug interactions
Chloramphenicol + Lonafarnib
Severity: Major
Chloramphenicol and Lonafarnib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A4 substrate, so CYP3A4 inhibition can markedly raise its exposure and gastrointestinal, renal and cardiac toxicity. Labeling contraindicates strong and moderate CYP3A4 inhibitors.
What this interaction means in plain words
Chloramphenicol and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Lonafarnib belongs to Miscellaneous.
Why it happens
CYP3A4 inhibition reduces lonafarnib metabolic clearance.
What to do
Avoid co-administration and select an alternative antibiotic. If unavoidable, hold or reduce lonafarnib per specialist guidance and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Lonafarnib?
MediHelp rates the interaction as major. Chloramphenicol and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a sensitive CYP3A4 substrate, so CYP3A4 inhibition can markedly raise its exposure and gastrointestinal, renal and cardiac toxicity. Labeling contraindicates strong and moderate CYP3A4 inhibitors.
How serious is the interaction between Chloramphenicol and Lonafarnib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-administration and select an alternative antibiotic. If unavoidable, hold or reduce lonafarnib per specialist guidance and monitor for toxicity.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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