Drug interactions
Chloramphenicol + Osilodrostat
Severity: Moderate
Chloramphenicol and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may increase osilodrostat concentrations through CYP3A4 inhibition. Excess exposure can cause over-suppression of cortisol (adrenal insufficiency) and QT prolongation.
What this interaction means in plain words
Chloramphenicol and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Osilodrostat belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated osilodrostat metabolism by chloramphenicol.
What to do
Consider halving the osilodrostat dose during co-therapy and monitor cortisol, symptoms of adrenal insufficiency and ECG/QT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Osilodrostat
Frequently asked questions
Can I take Chloramphenicol with Osilodrostat?
MediHelp rates the interaction as moderate. Chloramphenicol and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may increase osilodrostat concentrations through CYP3A4 inhibition. Excess exposure can cause over-suppression of cortisol (adrenal insufficiency) and QT prolongation.
How serious is the interaction between Chloramphenicol and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider halving the osilodrostat dose during co-therapy and monitor cortisol, symptoms of adrenal insufficiency and ECG/QT.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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