Drug interactions
Chloramphenicol + Ospemifene
Severity: Minor
Chloramphenicol and Ospemifene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits CYP2C19 and may modestly raise ospemifene concentrations. The clinical effect is probably small but could increase estrogen-agonist adverse effects.
What this interaction means in plain words
Chloramphenicol and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloramphenicol belongs to Anti Bacterial; Ospemifene belongs to Endocrine.
Why it happens
Inhibition of CYP2C19-mediated ospemifene metabolism by chloramphenicol.
What to do
No routine adjustment; monitor for ospemifene adverse effects such as hot flushes or thromboembolic symptoms during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloramphenicol
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Chloramphenicol with Ospemifene?
MediHelp rates the interaction as minor. Chloramphenicol and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol inhibits CYP2C19 and may modestly raise ospemifene concentrations. The clinical effect is probably small but could increase estrogen-agonist adverse effects.
How serious is the interaction between Chloramphenicol and Ospemifene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for ospemifene adverse effects such as hot flushes or thromboembolic symptoms during prolonged co-therapy.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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