Drug interactions
Chloramphenicol + Ribociclib
Severity: Major
Chloramphenicol and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a CYP3A4 substrate that causes neutropenia and QT prolongation, both of which may worsen with higher exposure. Chloramphenicol also suppresses bone marrow.
What this interaction means in plain words
Chloramphenicol and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Ribociclib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4 and adds myelosuppression.
What to do
Prefer another antibiotic. If combined, monitor ECG, electrolytes and blood counts, and reduce the ribociclib dose per labeling for CYP3A inhibitors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Ribociclib?
MediHelp rates the interaction as major. Chloramphenicol and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib is a CYP3A4 substrate that causes neutropenia and QT prolongation, both of which may worsen with higher exposure. Chloramphenicol also suppresses bone marrow.
How serious is the interaction between Chloramphenicol and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer another antibiotic. If combined, monitor ECG, electrolytes and blood counts, and reduce the ribociclib dose per labeling for CYP3A inhibitors.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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