Drug interactions
Chloramphenicol + Rimegepant
Severity: Moderate
Chloramphenicol and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rimegepant is metabolized by CYP3A4, so inhibition may increase exposure. Labeling advises against a second dose within 48 hours with moderate CYP3A4 inhibitors.
What this interaction means in plain words
Chloramphenicol and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Rimegepant belongs to Central Nervous System.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing rimegepant clearance.
What to do
Avoid taking a second rimegepant dose within 48 hours while on chloramphenicol. Monitor for headache, nausea and hypersensitivity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Rimegepant
Frequently asked questions
Can I take Chloramphenicol with Rimegepant?
MediHelp rates the interaction as moderate. Chloramphenicol and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rimegepant is metabolized by CYP3A4, so inhibition may increase exposure. Labeling advises against a second dose within 48 hours with moderate CYP3A4 inhibitors.
How serious is the interaction between Chloramphenicol and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking a second rimegepant dose within 48 hours while on chloramphenicol. Monitor for headache, nausea and hypersensitivity.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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