Drug interactions
Chloramphenicol + Ripretinib
Severity: Moderate
Chloramphenicol and Ripretinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ripretinib and its active metabolite are CYP3A4 substrates, so inhibition may increase exposure and adverse reactions such as palmar-plantar erythrodysesthesia, hypertension and myalgia.
What this interaction means in plain words
Chloramphenicol and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Ripretinib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing clearance of ripretinib and its active metabolite.
What to do
Monitor for adverse reactions and interrupt or dose-reduce ripretinib per labeling if toxicity occurs. Consider an alternative antibiotic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Ripretinib
- Amobarbital + Ripretinib Major
- Apalutamide + Ripretinib Major
- Carbamazepine + Ripretinib Major
- Efavirenz + Ripretinib Major
- Enzalutamide + Ripretinib Major
- Phenytoin + Ripretinib Major
Frequently asked questions
Can I take Chloramphenicol with Ripretinib?
MediHelp rates the interaction as moderate. Chloramphenicol and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ripretinib and its active metabolite are CYP3A4 substrates, so inhibition may increase exposure and adverse reactions such as palmar-plantar erythrodysesthesia, hypertension and myalgia.
How serious is the interaction between Chloramphenicol and Ripretinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse reactions and interrupt or dose-reduce ripretinib per labeling if toxicity occurs. Consider an alternative antibiotic if feasible.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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