Drug interactions
Chloramphenicol + Rivaroxaban
Severity: Moderate
Chloramphenicol and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may raise rivaroxaban concentrations by inhibiting CYP3A4, increasing the potential for bleeding. The magnitude is uncertain and probably smaller than with potent dual inhibitors.
What this interaction means in plain words
Chloramphenicol and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Rivaroxaban belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated rivaroxaban clearance.
What to do
Monitor for signs of bleeding and renal function. Consider an alternative antibiotic in patients with renal impairment or high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Chloramphenicol with Rivaroxaban?
MediHelp rates the interaction as moderate. Chloramphenicol and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may raise rivaroxaban concentrations by inhibiting CYP3A4, increasing the potential for bleeding. The magnitude is uncertain and probably smaller than with potent dual inhibitors.
How serious is the interaction between Chloramphenicol and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and renal function. Consider an alternative antibiotic in patients with renal impairment or high bleeding risk.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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