Drug interactions
Chloramphenicol + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Minor
Chloramphenicol and Sofosbuvir-velpatasvir-voxilaprevir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol can inhibit CYP3A4 and may raise velpatasvir concentrations. The clinical effect is expected to be small, and evidence is mostly theoretical.
What this interaction means in plain words
Chloramphenicol and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloramphenicol belongs to Anti Bacterial; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Chloramphenicol inhibits CYP3A4, a minor metabolic pathway for velpatasvir.
What to do
No dose change is needed; monitor for gastrointestinal effects and headache, and for hepatic tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as minor. Chloramphenicol and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol can inhibit CYP3A4 and may raise velpatasvir concentrations. The clinical effect is expected to be small, and evidence is mostly theoretical.
How serious is the interaction between Chloramphenicol and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for gastrointestinal effects and headache, and for hepatic tolerability.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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