Drug interactions
Chlordiazepoxide + Chlorpromazine
Severity: Moderate
Chlordiazepoxide and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are strongly sedating, and combining them can cause marked drowsiness, hypotension and impaired psychomotor function. Chlorpromazine can also lower the seizure threshold, which matters when benzodiazepines are used for withdrawal.
What this interaction means in plain words
Chlordiazepoxide and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension from GABA-A potentiation and chlorpromazine's H1, alpha-1 and D2 antagonism.
What to do
Monitor sedation, blood pressure and respiration, using the lowest effective doses. Take particular care in alcohol withdrawal and in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Chlorpromazine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are strongly sedating, and combining them can cause marked drowsiness, hypotension and impaired psychomotor function. Chlorpromazine can also lower the seizure threshold, which matters when benzodiazepines are used for withdrawal.
How serious is the interaction between Chlordiazepoxide and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and respiration, using the lowest effective doses. Take particular care in alcohol withdrawal and in older patients.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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