Drug interactions
Chlordiazepoxide + Lisdexamfetamine
Severity: Minor
Chlordiazepoxide and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stimulants can mask benzodiazepine sedation without correcting the impairment in judgment or psychomotor performance. The net effect is unpredictable and no clear harmful interaction is established.
What this interaction means in plain words
Chlordiazepoxide and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Opposing CNS effects from amphetamine catecholamine release and GABA-A potentiation; no established pharmacokinetic interaction.
What to do
No dose change is routinely needed. Advise patients not to judge driving fitness by perceived alertness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Lisdexamfetamine?
MediHelp rates the interaction as minor. Chlordiazepoxide and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stimulants can mask benzodiazepine sedation without correcting the impairment in judgment or psychomotor performance. The net effect is unpredictable and no clear harmful interaction is established.
How serious is the interaction between Chlordiazepoxide and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Advise patients not to judge driving fitness by perceived alertness.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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