Drug interactions
Chlordiazepoxide + Propofol
Severity: Major
Chlordiazepoxide and Propofol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines potentiate the sedative and hypnotic effects of propofol, which can deepen anesthesia, reduce propofol requirements and increase the risk of hypotension, apnea and airway obstruction.
What this interaction means in plain words
Chlordiazepoxide and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Synergistic GABA-A receptor potentiation producing additive CNS and respiratory depression.
What to do
Reduce propofol dose and titrate slowly to effect, with continuous monitoring of oxygen saturation, ventilation and blood pressure. Ensure airway support is immediately available and by trained staff only.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide
Other interactions of Propofol
Frequently asked questions
Can I take Chlordiazepoxide with Propofol?
MediHelp rates the interaction as major. Chlordiazepoxide and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines potentiate the sedative and hypnotic effects of propofol, which can deepen anesthesia, reduce propofol requirements and increase the risk of hypotension, apnea and airway obstruction.
How serious is the interaction between Chlordiazepoxide and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce propofol dose and titrate slowly to effect, with continuous monitoring of oxygen saturation, ventilation and blood pressure. Ensure airway support is immediately available and by trained staff only.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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