Drug interactions
Chlordiazepoxide-clidinium + Cinnarizine
Severity: Moderate
Chlordiazepoxide-clidinium and Cinnarizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine has sedating antihistamine properties and may add to benzodiazepine-induced drowsiness and impaired psychomotor performance.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Cinnarizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Cinnarizine belongs to Respiratory.
Why it happens
Additive CNS depression through H1 antagonism and GABAergic enhancement.
What to do
Monitor for excessive drowsiness and advise patients to avoid driving or hazardous tasks; lower doses if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Cinnarizine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Cinnarizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine has sedating antihistamine properties and may add to benzodiazepine-induced drowsiness and impaired psychomotor performance.
How serious is the interaction between Chlordiazepoxide-clidinium and Cinnarizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness and advise patients to avoid driving or hazardous tasks; lower doses if sedation is troublesome.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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