Drug interactions
Chlordiazepoxide-clidinium + Clarithromycin
Severity: Moderate
Chlordiazepoxide-clidinium and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase chlordiazepoxide exposure, intensifying and prolonging sedation and psychomotor impairment. Effect is more pronounced in older patients.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Clarithromycin belongs to Anti Bacterial.
Why it happens
Clarithromycin inhibits CYP3A4, reducing chlordiazepoxide clearance.
What to do
Monitor for oversedation and consider lowering the chlordiazepoxide dose during clarithromycin therapy, or choose an antibiotic that does not inhibit CYP3A4 such as azithromycin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Clarithromycin?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may increase chlordiazepoxide exposure, intensifying and prolonging sedation and psychomotor impairment. Effect is more pronounced in older patients.
How serious is the interaction between Chlordiazepoxide-clidinium and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider lowering the chlordiazepoxide dose during clarithromycin therapy, or choose an antibiotic that does not inhibit CYP3A4 such as azithromycin.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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