Drug interactions
Chlordiazepoxide-clidinium + Clobazam
Severity: Moderate
Chlordiazepoxide-clidinium and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines taken together add to each other's central nervous system depression. Sedation, impaired coordination, respiratory depression and falls are more likely, especially in older or frail patients.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Clobazam belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression through enhancement of GABA-A receptor activity.
What to do
Avoid routine duplication of benzodiazepines, and use the lowest effective doses if both are needed. Monitor sedation and respiratory status, and counsel on driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlordiazepoxide-clidinium and Clobazam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Clobazam?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two benzodiazepines taken together add to each other's central nervous system depression. Sedation, impaired coordination, respiratory depression and falls are more likely, especially in older or frail patients.
How serious is the interaction between Chlordiazepoxide-clidinium and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine duplication of benzodiazepines, and use the lowest effective doses if both are needed. Monitor sedation and respiratory status, and counsel on driving and alcohol.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
