Drug interactions
Chlordiazepoxide-clidinium + Darunavir
Severity: Moderate
Chlordiazepoxide-clidinium and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boosted darunavir can increase chlordiazepoxide levels, raising the risk of prolonged sedation and respiratory depression.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Darunavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 metabolism of chlordiazepoxide, mainly by the ritonavir or cobicistat booster.
What to do
Reduce the benzodiazepine dose and monitor for oversedation. Consider lorazepam, which is not CYP3A4 dependent, as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Darunavir?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Boosted darunavir can increase chlordiazepoxide levels, raising the risk of prolonged sedation and respiratory depression.
How serious is the interaction between Chlordiazepoxide-clidinium and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the benzodiazepine dose and monitor for oversedation. Consider lorazepam, which is not CYP3A4 dependent, as an alternative.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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