Drug interactions
Chlordiazepoxide-clidinium + Desflurane
Severity: Moderate
Chlordiazepoxide-clidinium and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines reduce the dose of inhalational anesthetic needed and can deepen sedation and respiratory and cardiovascular depression during anesthesia. Patients taking chlordiazepoxide may show enhanced anesthetic effects and prolonged recovery.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Desflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABAergic potentiation.
What to do
Anesthesia staff should titrate desflurane to effect with monitoring of depth of anesthesia, ventilation and hemodynamics, and anticipate delayed emergence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Desflurane
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Desflurane?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines reduce the dose of inhalational anesthetic needed and can deepen sedation and respiratory and cardiovascular depression during anesthesia. Patients taking chlordiazepoxide may show enhanced anesthetic effects and prolonged recovery.
How serious is the interaction between Chlordiazepoxide-clidinium and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Anesthesia staff should titrate desflurane to effect with monitoring of depth of anesthesia, ventilation and hemodynamics, and anticipate delayed emergence.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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