Drug interactions
Chlordiazepoxide-clidinium + Etomidate
Severity: Moderate
Chlordiazepoxide-clidinium and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines such as chlordiazepoxide can enhance the hypnotic effect of etomidate, so less anesthetic may be needed. Deeper sedation, hypotension or respiratory depression may occur.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Etomidate belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS depression.
What to do
Titrate etomidate to effect and consider a reduced induction dose. Monitor ventilation and blood pressure with airway support available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Etomidate?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines such as chlordiazepoxide can enhance the hypnotic effect of etomidate, so less anesthetic may be needed. Deeper sedation, hypotension or respiratory depression may occur.
How serious is the interaction between Chlordiazepoxide-clidinium and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate etomidate to effect and consider a reduced induction dose. Monitor ventilation and blood pressure with airway support available.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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