Drug interactions
Chlordiazepoxide-clidinium + Flibanserin
Severity: Major
Chlordiazepoxide-clidinium and Flibanserin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both flibanserin and chlordiazepoxide cause CNS depression. Combined use increases the risk of sedation, dizziness, hypotension and syncope.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Flibanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Flibanserin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Avoid combining where possible; flibanserin labeling advises caution and counseling on sedation and hypotension. Avoid alcohol and monitor for excessive sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Flibanserin?
MediHelp rates the interaction as major. Chlordiazepoxide-clidinium and Flibanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both flibanserin and chlordiazepoxide cause CNS depression. Combined use increases the risk of sedation, dizziness, hypotension and syncope.
How serious is the interaction between Chlordiazepoxide-clidinium and Flibanserin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; flibanserin labeling advises caution and counseling on sedation and hypotension. Avoid alcohol and monitor for excessive sedation.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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