Drug interactions
Chlordiazepoxide-clidinium + Haloperidol
Severity: Moderate
Chlordiazepoxide-clidinium and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and psychomotor slowing, and together the effect is additive. Haloperidol also has a risk of extrapyramidal effects and QT prolongation, which are not altered by the benzodiazepine, but oversedation can complicate assessment.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Haloperidol belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and dopamine D2 blockade.
What to do
Use the lowest effective doses and monitor sedation and respiratory status, especially in older adults. Reassess need for both agents regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Haloperidol?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and psychomotor slowing, and together the effect is additive. Haloperidol also has a risk of extrapyramidal effects and QT prolongation, which are not altered by the benzodiazepine, but oversedation can complicate assessment.
How serious is the interaction between Chlordiazepoxide-clidinium and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory status, especially in older adults. Reassess need for both agents regularly.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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