Drug interactions
Chlordiazepoxide-clidinium + Iloperidone
Severity: Moderate
Chlordiazepoxide-clidinium and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and iloperidone may also reduce chlordiazepoxide clearance, further increasing sedation and orthostatic effects.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression plus weak CYP3A4 inhibition by iloperidone.
What to do
Monitor for sedation, dizziness and orthostatic hypotension. Reduce the benzodiazepine dose if excess drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Iloperidone?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and iloperidone may also reduce chlordiazepoxide clearance, further increasing sedation and orthostatic effects.
How serious is the interaction between Chlordiazepoxide-clidinium and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and orthostatic hypotension. Reduce the benzodiazepine dose if excess drowsiness occurs.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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