Drug interactions
Chlordiazepoxide-clidinium + Itraconazole
Severity: Moderate
Chlordiazepoxide-clidinium and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 inhibitor and can raise chlordiazepoxide concentrations, prolonging and intensifying sedation. The effect is more likely with long-term or higher dosing and in older patients.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Itraconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated chlordiazepoxide metabolism by itraconazole.
What to do
Monitor for excess sedation and consider lowering the chlordiazepoxide dose during itraconazole therapy. Reassess if the azole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Itraconazole?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole is a strong CYP3A4 inhibitor and can raise chlordiazepoxide concentrations, prolonging and intensifying sedation. The effect is more likely with long-term or higher dosing and in older patients.
How serious is the interaction between Chlordiazepoxide-clidinium and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and consider lowering the chlordiazepoxide dose during itraconazole therapy. Reassess if the azole is stopped.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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