Drug interactions
Chlordiazepoxide-clidinium + Midazolam
Severity: Major
Chlordiazepoxide-clidinium and Midazolam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two benzodiazepines together, particularly with parenteral midazolam, produces additive sedation and respiratory depression. Procedural settings carry the highest risk of hypoventilation and apnea.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Midazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Midazolam belongs to Central Nervous System.
Why it happens
Both drugs potentiate GABA-A receptor activity, giving additive CNS and respiratory depression.
What to do
Reduce the midazolam dose and titrate slowly, with continuous monitoring of oxygen saturation and respiration. Avoid unnecessary benzodiazepine duplication.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Midazolam?
MediHelp rates the interaction as major. Chlordiazepoxide-clidinium and Midazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two benzodiazepines together, particularly with parenteral midazolam, produces additive sedation and respiratory depression. Procedural settings carry the highest risk of hypoventilation and apnea.
How serious is the interaction between Chlordiazepoxide-clidinium and Midazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the midazolam dose and titrate slowly, with continuous monitoring of oxygen saturation and respiration. Avoid unnecessary benzodiazepine duplication.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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