Drug interactions
Chlordiazepoxide-clidinium + Paliperidone
Severity: Moderate
Chlordiazepoxide-clidinium and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone with a benzodiazepine can increase drowsiness and psychomotor impairment, and orthostatic hypotension may occur. Older adults are at greater risk of falls.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and antipsychotic receptor blockade.
What to do
Monitor for sedation and orthostatic hypotension and use the lowest effective benzodiazepine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Paliperidone?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone with a benzodiazepine can increase drowsiness and psychomotor impairment, and orthostatic hypotension may occur. Older adults are at greater risk of falls.
How serious is the interaction between Chlordiazepoxide-clidinium and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension and use the lowest effective benzodiazepine dose.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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