Drug interactions
Chlordiazepoxide-clidinium + Perphenazine
Severity: Moderate
Chlordiazepoxide-clidinium and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is a sedating phenothiazine antipsychotic, and combined with a benzodiazepine it can produce additive drowsiness, psychomotor impairment and hypotension. Clidinium adds anticholinergic effects to those of perphenazine.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression (D2/H1 blockade plus GABA-A potentiation) with additive anticholinergic effects.
What to do
Monitor for oversedation, orthostatic hypotension and anticholinergic effects, and use the lowest effective doses. Counsel patients on driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Perphenazine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is a sedating phenothiazine antipsychotic, and combined with a benzodiazepine it can produce additive drowsiness, psychomotor impairment and hypotension. Clidinium adds anticholinergic effects to those of perphenazine.
How serious is the interaction between Chlordiazepoxide-clidinium and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, orthostatic hypotension and anticholinergic effects, and use the lowest effective doses. Counsel patients on driving and alcohol.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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