Drug interactions
Chlordiazepoxide-clidinium + Voriconazole
Severity: Moderate
Chlordiazepoxide-clidinium and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can reduce the metabolism of chlordiazepoxide and raise its concentrations, which may lengthen or deepen sedation and psychomotor impairment. The effect is better documented for CYP3A4-cleared benzodiazepines such as midazolam, so the magnitude for chlordiazepoxide is less certain.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 and CYP2C19, which are involved in chlordiazepoxide oxidation.
What to do
Monitor for excessive sedation and respiratory depression, and consider lowering the chlordiazepoxide dose while voriconazole is given. Consider a benzodiazepine cleared by glucuronidation, such as lorazepam, if prolonged co-therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Voriconazole?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can reduce the metabolism of chlordiazepoxide and raise its concentrations, which may lengthen or deepen sedation and psychomotor impairment. The effect is better documented for CYP3A4-cleared benzodiazepines such as midazolam, so the magnitude for chlordiazepoxide is less certain.
How serious is the interaction between Chlordiazepoxide-clidinium and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, and consider lowering the chlordiazepoxide dose while voriconazole is given. Consider a benzodiazepine cleared by glucuronidation, such as lorazepam, if prolonged co-therapy is needed.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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