Drug interactions
Chloroquine + Drospirenone
Severity: Minor
Chloroquine and Drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is not a clinically significant CYP3A4 inhibitor, so no meaningful rise in chloroquine levels is expected. The listed interaction is theoretical.
What this interaction means in plain words
Chloroquine and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Drospirenone belongs to Endocrine.
Why it happens
No established mechanism; theoretical weak CYP3A4 inhibition.
What to do
No action is needed beyond awareness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Drospirenone
Frequently asked questions
Can I take Chloroquine with Drospirenone?
MediHelp rates the interaction as minor. Chloroquine and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone is not a clinically significant CYP3A4 inhibitor, so no meaningful rise in chloroquine levels is expected. The listed interaction is theoretical.
How serious is the interaction between Chloroquine and Drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond awareness.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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