Drug interactions
Chloroquine + Istradefylline
Severity: Minor
Chloroquine and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg/day is a weak CYP3A4 inhibitor and may raise exposure of CYP3A4 substrates such as chloroquine. The effect is expected to be modest.
What this interaction means in plain words
Chloroquine and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline weakly inhibits CYP3A4, reducing chloroquine metabolism.
What to do
Monitor for chloroquine adverse effects at the higher istradefylline dose; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Chloroquine with Istradefylline?
MediHelp rates the interaction as minor. Chloroquine and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at 40 mg/day is a weak CYP3A4 inhibitor and may raise exposure of CYP3A4 substrates such as chloroquine. The effect is expected to be modest.
How serious is the interaction between Chloroquine and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for chloroquine adverse effects at the higher istradefylline dose; no routine dose change is needed.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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