Drug interactions
Chloroquine + Larotrectinib
Severity: Minor
Chloroquine and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with some inhibitory activity on CYP3A4, and chloroquine is partly metabolized by CYP3A4. Any rise in chloroquine exposure is expected to be small and of limited clinical consequence.
What this interaction means in plain words
Chloroquine and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Larotrectinib belongs to Oncology.
Why it happens
Possible weak inhibition of CYP3A4-mediated chloroquine metabolism.
What to do
No dose change is normally required; monitor for chloroquine adverse effects such as nausea or QT symptoms if both are used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Chloroquine with Larotrectinib?
MediHelp rates the interaction as minor. Chloroquine and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with some inhibitory activity on CYP3A4, and chloroquine is partly metabolized by CYP3A4. Any rise in chloroquine exposure is expected to be small and of limited clinical consequence.
How serious is the interaction between Chloroquine and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally required; monitor for chloroquine adverse effects such as nausea or QT symptoms if both are used long term.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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