Drug interactions
Chloroquine + Morphine
Severity: Minor
Chloroquine and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine is a weak CYP2D6 inhibitor, but morphine is cleared mainly by glucuronidation rather than CYP2D6, so a meaningful rise in morphine exposure is not expected. Any clinical effect is likely small.
What this interaction means in plain words
Chloroquine and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Morphine belongs to Musculoskeletal.
Why it happens
Possible weak CYP2D6 inhibition, which is of little relevance to morphine's glucuronidation-based clearance.
What to do
No dose change is needed; monitor analgesic response and adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Morphine?
MediHelp rates the interaction as minor. Chloroquine and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloroquine is a weak CYP2D6 inhibitor, but morphine is cleared mainly by glucuronidation rather than CYP2D6, so a meaningful rise in morphine exposure is not expected. Any clinical effect is likely small.
How serious is the interaction between Chloroquine and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor analgesic response and adverse effects as usual.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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